because I would love to have maps the old way like in Doom where a shotgun Zombie or a pistol Zombie drop nothing or bullets but not a weapon. maybe for the Shotgun-Zombie like "Drop weapon - yes/no". so you can write "Level 01" or "Floor 03" or "I wuz here" or "Jon ate Garfield" or whatever!? Maybe some symbols you can put on walls with numbers and letters and signs and so on. Like the blood-spot you can use on the floor or wall and so on. something you can put on walls for decorations. but I guess that is too difficult and will stay a dream. Best would be an ingame-editor for own textures. and more endless textures for walls and ceilings and so on. more different stone textures (Like the ashtar ones. different plain metal textures with rivet studs. one with a background of mountains and clouds you can change colors for blue sky and white clouds and red sky and clouds for alien planet atmosphear and so on. one with only stars and dark space to create maps on a spaceship or on platforms in space. Or the futher levels will have a look on its own if they cam out in future levels. only two different so far and not a single one only with stars so you cannot make space-levels in a spaceship or on platforms in space or something like that.īut to bring in new textures will be difficult because. There has to be more stone-texutres and more textures for the floor and the ceiling to create different looking maps for the comunity.Īnd no wooden textures are in it at the moment and no textures for living flesh to create something structurated living material like in Doom or Quake 3 Arena and so on.Īlso the Skyboxes. You can do good levels with it but the amount of the textures is not that big at the moment like in other editors. The amount of monsters who only scratch or bite is minimal. Or a small doglike thing (Not that big like the four legged cowlike monster already in the game) that runs fast and bites or something like that. for long distance attacks but without shoting effects. something between the slow Zombie and the Shotgun-Zombie. Maybe some sort of a fast running and/or jumping Zombie. I would like to have more monsters for the beginning of the game. That means only harder and bigger monsters can be added and no primitve monsters for the beginning. So there will be only new levels after the ones that are already in the campaign. the campaign or the first couple of maps in it is set. and when!?īut I think to add new content (Textures, Monsters) will be difficult now.
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Either they enrich the life of your pets, or they make your job easier as their owner and caregiver.
Finally, by in silico structural analysis, we propose that Ca ++ binding to hPrP 90–231 modifies amino acid orientation, in the same way induced by E200K mutation, thus suggesting a pathway for the structural alterations responsible of PrP neurotoxicity.Ĭitation: Sorrentino S, Bucciarelli T, Corsaro A, Tosatto A, Thellung S, Villa V, et al. These features, either acquired after controlled thermal denaturation or induced by D202N and E200K mutations were previously identified as responsible for hPrP 90–231 cytotoxicity. We also report that Ca ++ binding to hPrP 90–231 induces a conformational change based on an alteration of secondary structure characterized by loss of alpha-helix content causing hydrophobic amino acid exposure and proteinase K resistance. A similar correlation between increased membrane conductance and cell degeneration has been observed assaying hPrP 90–231 bearing pathogenic mutations (D202N and E200K). Furthermore we show the existence of a direct link between these two effects as demonstrated by a highly statistically significant correlation in several experimental conditions. In the present study we demonstrate that hPrP 90–231, pre-incubated with 10 mM Ca ++ and then re-suspended in physiological external solution increases not only membrane conductance but neurotoxicity as well. We previously showed that the human PrP fragment 90–231 (hPrP 90–231) increases ionic conductance across artificial lipid bilayer, in a calcium-dependent manner, producing an alteration similar to that observed for PrP Sc. PrP Sc extracted from infected Syrian hamster brains induces a considerable change in membrane ionic conductance, although the contribution of this interaction to the molecular mechanism of neurodegeneration process is still controversial. 18, 4439–4450 ( 1998).The pathological form of prion protein (PrP Sc), as other amyloidogenic proteins, causes a marked increase of membrane permeability. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. Keller, J.N., Guo, Q., Holtsberg, F.W., Bruce-Keller, A.J. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. Calcium ionophore increases amyloid beta peptide production by cultured cells. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: Reduced oxidative stress and preserved mitochondrial function. The presenilin 2 loop domain interacts with the μ-calpain C-terminal region. Interaction of presenilins with the filamin family of actin-binding proteins. Zhang, W., Han, S.W., McKeel, D.W., Goate, A. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Presenilins are processed by caspase-type proteases. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Kim, T.-W., Pettingell, W.H., Jung, Y.-K., Kovacs, D.M. Identification of neuronal calcium sensor (NCS-1) possibly involved in the regulation of receptor phosphorylation. Nef, S., Fiumelli, H., de Castro, E., Raes, M.B. Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus. Kobayashi, M., Takamatsu, K., Saitoh, S., Miura, M. Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. Prediction of the coding sequences of unidentified human genes. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. Amyloid, the presenilins and Alzheimer's disease. Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. et al.Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. et al.Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Sherrington,R, et al.Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. 3/4' or thinner, 5-6 minutes maximum per side, thicker than 3/4' 6-7 minutes maximum per side. Cooking time for second side is shorter by 1-2 minutes. Remove from marinade and cook over medium-high heat on greased grill for no more than 15 minutes or until done. Seasonings: I use my very own homemade barbecue rub, which is pretty amazing Read on to learn how to make a homemade BBQ dry rub. Place the marinated pork chops directly on the grill grates. In deep bowl mix all marinade ingredients. I put garlic pepper on just about everything coming out of my kitchen. Here’s what you need: Pork chops: I use bone-in pork chops, but feel free to use boneless pork chops or pork steaks. But feel free to experiment with your favorite seasonings. With this basic recipe, it just uses salt and pepper. Cheeseburger Macaroni in the Instant Pot.Use something like parchment paper to place down on the pan before cooking and clean-up is even easier! More One-Pan Dishes You’ll Love: So one-pan dishes are my ultimate favorite because that makes clean-up a breeze. Plus, one-pan dishes usually include veggies and the protein all-in-one, and it takes so much of the guesswork out of dinner time. More Pork Chop Recipes You’ll Love:ĭo you love one-pan recipes as much as I do? I mean, I know there are a TON of recipes here on the blog, and I like cooking… but I truly think I’d love it even more if I didn’t have a ton of dishes to clean up when I cooked. So, I wanted to come up with a few different recipes to keep in your recipe arsenal and this Sheet Pan Baked Boneless Pork Chops recipe is one of a few you’ll find here on the blog. I totally understand because they seem to be a more affordable pork option at the store. Baked Pork Chops and VeggiesĮver since I shared my Pan Fried Pork Chops recipe a couple of years ago, I’ve found that you all LOVE pork chops. Baked Pork Chops and Veggies – A one-pan oven baked recipe with veggies for a healthy weeknight dish, using everyday ingredients. Our fully customizable templates let you personalize your estimates for every client.Showcase your business, get hired and get paid fast with your premium profile, instant invoicing and online payment system. Boost your online presence and work efficiency with our lead management software, targeted local advertising and website services.Software for General Contractors Are you a professional General Contractor? Houzz Pro makes software designed to make running your business easier. You can also search for photos in Michigan and contact the Michigan general contractor who worked on the project. Narrow your search in the Professionals section of the website to Michigan general contracting companies. Are there any important considerations or concerns you foresee with this project? Find local contractors on Houzz.What happens when costs exceed budget, whether due to materials or labor pricing changes? What about changes made by the client or by the professionals - what kinds of situations would cause those costs to be incurred?.How do you charge, and what does that include?.What qualities do you look for in your subcontractors?.How many projects like mine have you completed?.How long have you been in the business?.Questions to ask prospective Michigan general contractors: Once you secure your local Michigan contractors, read the contract very carefully to be sure everyone is on the same page. You should call references, carefully read reviews and visit completed projects in Michigan to see if they’re what you expect for your job. Was it ready when the contractor promised it? Was the bid for building a home unusually high or low? Each of these things can be very telling: A late bid may reflect timing standards, and an off-the-mark bid could be code for a pricey premium or a deliberate underbid to score the remodeling job. Because of this, it's essential that you do your homework before deciding on the right professional contractors in Michigan as you remodel or build a house. General contracting services are a must for successful completion of a renovation. In addition, home renovation contractors should be on-site regularly to inspect the progress and resolve issues. While good local home improvement contractors in Michigan will have the skills to handle certain tasks onsite, such as carpentry, he or she is also responsible for hiring subcontractors for the majority of jobs, such as electrical work, painting or plumbing. A Michigan general building contractor will work with your architect to review plans as you build a house and ensure everything is in place before work is started as well as arrange for permits and necessary inspections. They oversee the entire remodeling or new home construction project and facilitate all day-to-day tasks that move it toward completion. What is a general contractor? General, or construction contractors, are often known as project managers. Whether you’re trying to find Michigan building contractors for a new construction, or home renovation contractors to spruce up your existing place, it’s important to know exactly what role they will play in the project. These professional contractors manage all aspects of the job to ensure it's completed on schedule and to your satisfaction. If you're on the brink of a large home improvement project, remodel, or new build, you'll likely want to hire a general contractor in Michigan. Video (Markerless): A sophisticated camera stage is usedĪctors do not use suit markers of any kind. This isn’t used often anymore as the actors also need to carry some kind of charger or battery case, and the LED light can potentially spill into other filmed elements. Light-emitting LED markets are placed on actors the same way as optical-passive tracking, and special cameras record their movement. Optical-Active: LED suit markers & cameras However, it can be resource-hungry and isn’t suitable to run on entry-level systems. Historically, this was the most common way of doing motion capture. Large studios commonly use this type as it's the most accurate, yielding the impressive photorealistic tracking required for feature films. Retroreflective markers are placed on actors via a tight-fitting suit and tracked via infrared cameras. Optical-Passive: Retroreflective suit markers & infrared cameras What to consider when starting a motion capture project?įirst, you need to be aware of the four main types of motion capture, what they mean, and how to choose one that best fits your project needs. In the military, mocap is used to create advanced simulations and improve training programs.It’s been used to do everything from optimizing an athlete’s tennis swing to injury diagnosis and rehabilitation. The health and sports industry is a big user of motion capture technology.And that’s what mocap helps animators achieve. Humanoid fantasy characters need to move realistically to avoid the uncanny valley effect.In complex scenes, directors will often use mocap to block out the motions of the scene and more accurately prepare for shooting and VFX. It’s when the creators bring the static storyboard to life. Previs (also known as previsualization) happens during pre-production.Game animations use mocap to quickly build up a vast library of motions for each game character.Motion capture can be used for many types of projects, not just VFX. What applications are suitable for motion capture? It’s now possible to record movement from popular domestic animals such as dogs and horses. Keep reading until the end of the article to see a video of what that looked like in practice.įrom then on, mocap has become an almost mandatory feature in major films requiring VFX. In the late 2010’s motion capture evolved from tracking humans to tracking animals. The animated character interacted realistically with his live-action co-stars by relying on the mocap technique developed by Weta studios. In the next few years, it was quickly popularized by the then-revolutionary animated character Gollum in The Lord of the Rings. Motion capture was first used in the film Sinbad: Beyond the Veil of Mists (2000). The rise of motion capture as a Hollywood must-have It’s a similar technology that is used in Rokoko’s facial mocap app for iOS, which allows 3D artists to capture facial motions as blendshapes to apply them on their custom characters in their 3D animation projects. For example, Instagram filters use a type of mocap to track your face in real-time and apply simple animation overlays. With evolving technology, you can even use your cellphone to do basic motion capture. Motion capture records movement and translates it into data that can be read by animation software and applied to a 3D rig or character. It's a common misconception that motion capture projects need a big budget and an entire production team. Physical mocap suits, specialty cameras, and advanced software are used to create photorealistic animations that can be used in film, sports, and even healthcare. Motion capture (mocap) technology is used to record movements and apply them to a 3D model. The combination of food remains, along with bacteria and other elements, build up on the teeth and create the sticky substance known as plaque. How do plaque and tartar build up on teeth?ĭental plaque is formed by the accumulation of food debris on the tooth surface, which is colonized by various bacteria found in the oral cavity that feed on these debris. So essentially, when discussing plaque vs tartar, tartar is the progressed and more dangerous plaque. If you have tartar on your teeth, you’ll have to go to the dentist as soon as possible to remove it and prevent disease. The consistency of each is closely related to another of the main differences between plaque and tartar: plaque removal is simple vs tartar removal, which is a bit more complicated. Unlike plaque, which is sticky, tartar is hard. So, what’s the difference between plaque vs tartar?īasically, tartar is the next level of plaque. Tartar or dental calculus can accumulate in the molars, in other teeth and in the gums, where it is more difficult to remove. When we don’t brush our teeth properly, the accumulation of plaque can solidify, giving rise to tartar. Among other oral diseases, the accumulation of bacterial plaque is the main cause of cavities and gingivitis, hence its need for removal.Īnd what is tartar and why is it on teeth? Well, the tartar on teeth is simply the calcification of dental plaque, which is why it’s also referred to as dental calculus or calculus teeth. Wondering what if that stuff on your teeth is plaque, tartar or dental calculus? Let’s start by taking a look at plaque: what is it and what is doing on the teeth? The plaque that you can find on teeth is a sticky and colorless layer that builds up on the tooth surface due to the accumulation of bacteria and food debris. We’ll tell you everything you need to know about dental plaque and tartar. In this article we’ll take a look at both: we will show you what types of plaque and tartar exist, how to prevent them and how to remove them from your teeth once and for all. Dental tartar and bacterial plaque on teeth: what is it? Surely you have heard these two concepts at some point in your life and, whether you know what they are or not, you’ve probably heard that neither of them is very pleasant. There was one tour that year and one training camp.įemale soccer players earn 25 cents to the dollar of men at World Cup, new CNN analysis finds “Amateurish” and “half-put together,” is how Michelle Akers describes her first 12 months with the USWNT. It is strange to think that a player who would become a soccer great, who scored 105 goals in 153 international matches, who was named ‘Female player of the 20th Century’ by FIFA – the sport’s world governing body – didn’t understand she was representing her country when she received her first call up to the national team. ‘I didn’t understand what the national team was’ “And then we found comparable alpha female warriors that also embraced that.” “We took what was sort of unique to the American personality and injected it into our team,” he says. The team’s playing style was, he says, reflective of the American spirit. He was aggressive on the pitch, he says, and loved a duel which, unsurprisingly, his players excelled at. “We tried to make every team we played against suffer for 90 minutes, and that was our specialty.”Ĭoaches mould teams in their own personality, says Dorrance. “We had an amazing opportunity to make a mark in a sport the world invented. “We went in there with absolute reckless abandon,” he says. Perhaps crucially of all, came a change of mentality. Out went the 4-4-2 playing formation used by the majority of the men’s and women’s team of the age for a 3-4-3 system which had an emphasis on pressing – hurrying the opposition into mistakes, pressurizing them when they had the ball. In came a crop of young talent, many of whom he worked with at the University of North Carolina where he continues to be head coach. The list is long of what the USWNT didn’t have in those early years – facilities, support, history, expectation – but Dorrance had a blueprint for a better, successful future. We were going to take the world on at its own game,” says Dorrance. There was no money to be made and only one person had thoughts of world domination. This was the late 1980s, when USWNT players would sew badges onto their oversized hand-me-down kits from the men’s national team, buy their own cleats, and receive $10 a day when on national duty. What you need to know ahead of the 2023 Women’s World Cup (Photo by Richard Heathcote/Getty Images) Richard Heathcote/Getty Images LYON, FRANCE - JULY 07: Carli Lloyd of the USA lifts the trophy as USA celebrate victory during the 2019 FIFA Women's World Cup France Final match between The United State of America and The Netherlands at Stade de Lyon on Jin Lyon, France. Trophies? That would have been an absurd thought – not that there were many tournaments for female soccer players to compete in. When Dorrance took charge of the national team in 1986, training camps were rare and winning rarer. “You’re trying to do things that have never been done,” he tells CNN Sport.Īny understanding of how and why the USWNT is women’s soccer’s dominant force, a four-time Women’s World Cup winner and favorite to win the next edition currently taking place in Australia and New Zealand, must start with Dorrance, the groundbreaker and the bricklayer. We reached out, grabbed them by the throat and tried to squeeze the air out of them.”Įvery dynasty has a beginning, that someone or something which sets in motion the line of succession the visionary with the ambitious plan, aiming for a future others think fanciful the iron-willed followers bringing it to fruition, leaving unshakable foundations from which others can build.Īnson Dorrance knew he was a pioneer during his eight years as head coach of the US Women’s National Team (USWNT). “They thought we couldn’t play so we went into every game with a huge chip on our shoulders and we went after teams. Here are all 28 Honkai: Star Rail characters, ranked. Overall, it considers how useful characters are in a variety of team comps, even if they can work in niche settings. That means a character who doesn’t get better after a couple of Eidolons will rank lower than a character who does. Our tier list ranks characters based on their skills and utility without any Eidolons (copies of the same character), but it does account for their potential for improvement. You can probably build most characters to work if you level up their Light Cones and apply effective gear, but some will make it easier for you than others. Honkai: Star Rail is now live See the latest news: Dan Heng is a 4 Star Wind element playable character Honkai: Star Rail voiced by Nicholas Leung. In fact, I’d consider some of them to be better than the characters on the standard banner. Dan Heng, the cold and reserved train guard and archivist of the. Future updates, like the upcoming Kafka banner, will continue to do the same.īut even with all these cool characters, the ones that you get for free or from the standard banner should be enough to get you through much of the story. In addition to this, HoYoverse has officially announced that the next update will bring three new playable characters, Dan Heng, Fu Xuan, and Lynx, that players will be able to pull from their respective banners. You are the sun, the moon, and all in between. You are a formless void, drifting amongst the sea between asleep and awake. Since the game’s launch, new characters like Jing Yuan and Blade have shaken up the meta. Honkai: Star Rail 1.2 update has just gotten released, and the leaks for version 1.3 are already out. Dom Dan Heng (Honkai: Star Rail) Sub Caelus (Honkai: Star Rail) No Beta we die like our respect for Shampoo Costco. Honkai: Star Rail has many, many characters, some more worth investing in than others. He's the only elected official in the area-there's no sign of a town council or any sort of state or federal government-and yet has time to interact with all of the other characters on a daily basis. A lighthearted example occurs in LazyTown with Mayor Milford Meanswell.Although, following a Zombie Apocalypse, it is likely that some decentralization of power occurred during the collapse of society. The show In the Flesh depicts UK MPs and Parish Councils as having far more power and day-to-day involvement in their districts than they actually do in reality.Since Karlsville itself is a supernatural environment controlled by Karl, he's a full-blown Reality Warper while inside of it. Justified in the Goosebumps multi-part episode "Chillogy", whose Monster of the Week, known only as Karl, is the mayor of a miniature town that sucks kids into it so he can torment and kill them.On The Dukes of Hazzard, Boss Hogg's title was County Commissioner and was apparently the highest authority to cheat and steal from everyone.He has been making Sunnydale a haven for demonic activity for a century. Affably Evil Mayor Richard Wilkins in Buffy the Vampire Slayer.In this case, because they are the commanding officers of the space station, which is an Earth military base despite also functioning as a commerce hub and meeting place for the various major powers, and because during the Shadow War they declare independence from the fascist regime that's taken over Earth. Sinclair, Sheridan and Lochley in Babylon 5. He only ran because all the other candidates where either blatantly evil villains, murdered during their campaign or both and he's been under suspicion or indictment nearly his entire term. He makes unilateral decisions for the city that would realistically have to be put to voter referendum and intentionally undercuts the city council when he doesn't like their decisions. His mayoral staff is full of his family and friends, most of whom have criminal records, have been kicked out of other branches of local and federal service, and have no political experience whatsoever. that is, a Mayberry citizen or someone he knows to have a meager income might only have to pay very little (Andy explains the standard fine is $5, which is sizable for a violator but not enough to break them), as he knows Danny is very wealthy, he bumped the fine to $100, which Danny can easily afford and can serve as an effective punishment for breaking a traffic law. Andy explains that this is scaled justice. In the pilot only, he serves not only as sheriff, but mayor, justice of the peace and even newspaper editor, which (to Danny's dismay) he learns as he tries to get out of paying a large fine for failure to stop at a stop sign. The Andy Griffith Show: The pilot episode from its parent show, Make Room For Daddy, has the earlier show's main character, Danny Williams (played by comedian and nightclub singer Danny Thomas) arrested by the town's sheriff, Andy Taylor (played by Andy Griffith).Pretty much the raison d'etre of the show. Sherriff Lucas Buck from American Gothic (1995).Often overlaps with Permanent Elected Official. Other settings may use other authority figures the principal in a school setting, or the base commander in a military setting, for example. Expect such a mayor to be around forever, heedless of minor details like elections or competence. Whether they have a brilliant scheme that needs a powerful backer or they're trying to deal with the mayor's latest crackpot scheme to revitalize the town, they'll be able to (and, in fact, be forced to) go straight to the mayor himself instead of dealing with bureaucracy or procedure. This allows the characters to interact directly with the person in charge, without having to deal with annoyances like referendums or town councils. If such lofty figures show up at all, it will probably be in the form of an Obstructive Bureaucrat who buzzes around for a while before being subdued, allowing things to return to normal. They never have to worry about overstepping their authority, or having their decisions overruled by the county, state, or - God forbid - federal government. In these cases, the highest authority appearing in the work - often the local mayor - is treated as if he has absolute authority over his domain. Fiction often focuses on a local setting the action may rarely, if ever, move beyond the borders of the town where the main characters live. |
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