![]() ![]() Progressively, these highly selective approaches favoured the development of the term ‘Precision Medicine’ (PM) (still often used interchangeably with the older term ‘Personalized Medicine’ 1), which gained favour because it is objectively attractive and also conveys the reassuring feeling that doctors have therapies that are just ‘right for us’. What followed were the introduction of safe blood transfusions and of specific antibiotics against different types of bacteria. It happened with the discovery of blood typing and with the realization that invisible forms of life identifiable by a microscope could cause fatal infections. Medicine evolves steadily but sometimes new ideas or discoveries lead to either sudden turns or abrupt jumps forward. ![]() Nonetheless, its potential superiority over standard therapies should be constantly monitored and assessed before translating intellectually rewarding new discoveries into clinical practice. We believe that PM may shape the diagnosis and treatment of cardiac channelopathies for years to come. Thus, our own eagerness to implement the most recent translational strategies for cardiac channelopathies must be tempered by an objective assessment to verify whether the PM approaches are indeed making a difference for the patients. This point matters because the new approaches may, or may not, exceed the efficacy and safety of established therapies. We have indeed tried to provide the cardiologist’s point of view by comparing state-of-the-art techniques and approaches, including revolutionary discoveries, to current practice. PM is where scientists and clinicians must meet and integrate their expertise to improve medical care in an innovative way but without losing common sense. Here, we have explored the main layers that should be considered when developing a PM approach for cardiac channelopathies, with a focus on modern in vitro strategies based on patient-specific human-induced pluripotent stem cells and on in silico models. Cardiac channelopathies are being progressively involved in the evolution brought by PM and some of them are benefiting from these novel approaches, especially the long QT syndrome. Precision Medicine (PM) is an innovative approach that, by relying on large populations’ datasets, patients’ genetics and characteristics, and advanced technologies, aims at improving risk stratification and at identifying patient-specific management through targeted diagnostic and therapeutic strategies. ![]()
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